N.F.L. Week 6 Picks Against the Spread

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Kansas City at Tennessee Titans, 1 p.m., CBS

Line: Kansas City -4.5 | Total: 56.5

Kansas City safety Tyrann Mathieu has seen enough.

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Television cameras caught his emotional dialogues with his teammates on the bench and his hands above his head in confusion on the field after poor defensive performances and breakdowns.

The team ranks 28th in rushing defense, a nightmare for Kansas City (3-3) as it faces the Titans (4-2) and Derrick Henry, the N.F.L.’s leading rusher. The offense is not helping the defending A.F.C. champion, either. Kansas City leads the N.F.L. in turnovers (14), and Patrick Mahomes’s eight interceptions are tied for second with Jaguars rookie Trevor Lawrence. After watching the Bills, the Chargers and the Ravens contain Kansas City, the Titans’ defense could do the same, or at least keep the game competitive enough to allow Henry and the offense to cover the spread. Pick: Titans +4.5

Cincinnati Bengals at Baltimore Ravens, 1 p.m., CBS

Line: Ravens -6 | Total: 47

The Ravens (5-1) have shown they can win in several ways. Lamar Jackson can throw for over 400 yards or the team can amass 200 rushing yards. Four of the team’s six games have been decided by one score, and the matchup with the Bengals (4-2) could be just as close.

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Cincinnati’s defense ranks ninth in rushing yards allowed (543), meaning Baltimore may have to rely more heavily on Jackson’s arm. Joe Burrow and the rookie wideout Ja’Marr Chase, who ranks fourth in the league in receiving yards (553), are capable of making it a shootout. Expect the Bengals to keep the game close. Pick: Bengals +6

Indianapolis Colts at San Francisco 49ers, 8:20 p.m., NBC

Line: 49ers -3.5 | Total: 44

San Francisco (2-3) could join Seattle on the brink of irrelevancy in the N.F.C. West with another loss, while the Rams and the Cardinals have winnable games.

Jimmy Garoppolo (calf) is likely to start as the rookie Trey Lance recovers from a knee injury. But he will be without tight end George Kittle (calf), who was put on injured reserve before last week’s bye.

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