Everton: Jordan Pickford (GK), James Tarkowski, Conor Coady, Ben Godfrey, Seamus Coleman (c), Alex Iwobi, Amadou Onana, Idrissa Gueye, Vitaly Mykolenko, Demarai Gray, Dominic Calvert-Lewin
Substitutes: Begovic, Mina, Holgate, Davies, McNeil, Doucoure, Maupay, Simms, Gordon
Southampton: Gavin Bazunu (GK), Duje Caleta-Car, Lyanco, Mohammed Salisu, Romeo Lavia, Kyle Walker-Peters, James Ward-Prowse (c), Mohammed Elyounoussi, Ibrahima Diallo, Samuel Edozie, Che Adams
Substitutes: Caballero, Perraud, Aribo, Orsic, Alcaraz, Maitland-Niles, Djenepo, Mara, Armstrong
Despite being stretchered off in Everton’s FA Cup loss against Manchester United last weekend, Iwobi starts for Everton in a side with three changes from the starting XI that faced Brighton in their last league game, with Godfrey, Coleman and Onana coming on for Dwight McNeil, Tom Davies and the injured Nathan Patterson.
Two changes for Southampton from their last league game, one enforced by Armel Bella-Kotchap injured; he and Sekou Mara make way for Diallo and Caleta-Car. Their newest player Carlos Alcaraz, announced after their victory over City, starts on the bench.